You have been diagnosed with pulmonary hypertension … now what? Although there is currently no cure for pulmonary hypertension, there are treatment options available and more are on the horizon. Treatments include conventional medical therapies and oral, inhaled, intravenous (into the vein) and subcutaneous (into the skin) options. Depending on the severity of PH, heart or lung transplant may also be an option.

Remember that each patient is different. It is essential that you talk to your own doctor about what treatment options are best for you.

Fact Sheets Issued by PH’s Scientific Leadership Council

Conventional Medical Therapies

  • Calcium Channel Blockers (CCB) – Help decrease blood pressure (Only appropriate for a small minority of patients demonstrating a favorable response to vasodilator testing at the time of heart catheterization.)
  • Digoxin – Assists the pumping of the heart
  • Diuretics – Rids excess fluid that puts pressure on the heart
  • Oxygen – Inhaled by patients via a nasal cannula or face mask
  • Warfarin (Coumadin®) – “Thins” blood and prevents it from clotting Oral Treatment Options Endothelin Receptor Antagonists (ERAs) help prevent blood vessels from narrowing.
  • Ambrisentan (Letairis®)
  • Bosentan (Tracleer®)
  • Macitentan (Opsumit®)

Phosphodiesterase Inhibitors (PDE 5 Inhibitors) allow the lungs to produce more of its own natural vasodilators.

  • Sildenafil (Revatio™)
  • Sildenafil (Revatio™) for Pediatric Use
  • Tadalafil (Adcirca®)

Prostacyclin Analogue

  • Oral Treprostinil (Orenitram®)

Prostacyclin Receptor Agonist

  • Oral Selexipag (Uptravi®)

Soluble Guanylate Cyclase Stimulators

  • Riociguat (Adempas®)

Inhaled Treatment Options

Inhaled Treatment Options, such as prostacyclins, relieve shortness of breath.

  • Iloprost (Ventavis®)
  • Inhaled Treprostinil (Tyvaso™)

Intravenous Treatment Options

Intravenous Treatment Options open up the blood vessels and help ease symptoms of PH, including chest pain and shortness of breath.

  • Intravenous Treprostinil (Remodulin®)
  • Epoprostenol (Flolan®)
  • Room Temperature Stable Epoprostenol (Veletri®)

Subcutaneous Treatment Options

Subcutaneous Treatment Options are delivered through a portable infusion pump to open up the blood vessels and ease the symptoms of PH.

  • Subcutaneous Treprostinil (Remodulin®)

Research and Clinical Trials

Lung Transplantation